13 Sep 2025

Blueberries and brain health in midlife

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Berries have long been appreciated for their delicious flavor and their nutritional profile. Among them, the blueberry stands out not only as a gastronomic delicacy but also as a growing subject of scientific interest for its potential health benefits, particularly for cognitive function.

Recent research highlights how blueberry supplementation may play a crucial role in preventing cognitive decline, especially in midlife, opening new perspectives for brain health.

The role of blueberries in reducing dementia risk in midlife

Dementia, which often manifests in old age, has roots that can develop as early as midlife. Metabolic alterations, common in this stage of life, are recognized as a significant risk factor for dementia.

In this context, a randomized controlled trial explored the effects of daily blueberry supplementation in a sample of overweight men and women aged 50 to 65, with insulin resistance and subjective cognitive decline (SCD). SCD is the perception of having memory or thinking problems, often considered an early warning sign of possible future cognitive issues.

The results of this study were particularly encouraging. The group that consumed blueberries showed significant improvements in word recall ability (lexical access) and in managing memory distractions.

Moreover, participants reported a reduction in difficulties during the "encoding" phase of memory in daily activities. At the metabolic level, there was a correction of excess insulin in the blood (peripheral hyperinsulinemia) and a modest trend toward optimizing mitochondrial activity, the cells’ "powerhouses."

These cognitive and energetic benefits are attributed to the action of the bioactive compounds present in blueberries, such as anthocyanins and proanthocyanidins.

Beyond cognition: the broad spectrum of berry benefits

Scientific interest in blueberries does not stop at preventing cognitive decline in midlife. Further research is underway to explore their impact on brain health.

For example, a randomized controlled trial has been outlined to assess the effects of blueberry consumption on brain health in elderly individuals.

Other studies have examined the chronic and postprandial effects of blueberries on cognitive function, attention, and mood in people with metabolic syndrome.

There is also evidence that blueberry juice may enhance exercise-induced neuroprotection in preclinical models of Parkinson’s disease.

This research landscape underscores the multifactorial potential of blueberries and, more broadly, of berries in promoting overall well-being.

Berries in a functional diet

Emerging scientific evidence on blueberries and their benefits for cognitive function and metabolism, particularly during a crucial stage such as midlife, suggests significant potential for including them in daily diets.

Early implementation of dietary habits that regularly include blueberries may represent a useful strategy for protecting against cognitive decline, contributing to a proactive approach to health.

This positions berries as valuable elements of a modern diet, focused on well-being and functionality, supporting healthy aging and improved quality of life.

Source: Krikorian R, Skelton MR, Summer SS, Shidler MD, Sullivan PG. Blueberry Supplementation in Midlife for Dementia Risk Reduction. Nutrients. 2022 Apr 13;14(8):1619. doi: 10.3390/nu14081619. PMID: 35458181; PMCID: PMC9031005. 

🫐  Well-being & Health with Berries 🍓 

This article is part of the editorial series Wellness & Health with Berries, which brings scientific research closer to everyday life, promoting berries as allies for well-being.

The series offers clear, up-to-date, and evidence-based content designed to inform consumers and support all operators in the berry supply chain.

👉 View the full series


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